To Evaluate the Efficacy of Diquafosol Sodium in the Treatment of MGD in Different Treatment Pattern
Status:
Not yet recruiting
Trial end date:
2025-05-20
Target enrollment:
Participant gender:
Summary
MGD is a chronic, diffuse abnormality of the meibomian glands, commonly characterized by
terminal duct obstruction and/or qualitative/quantitative changes in the glandular secretion.
It may result in alteration of the tear film, symptoms of eye irritation, clinically apparent
inflammation, and ocular surface disease. The meibomian glands, found in the upper and lower
eyelids, excrete lipids onto the ocular surface that forms the outermost layer of the tear
film, lubricating the ocular surface during blinking and protecting against tear
evaporation.1 2 Through dysfunction of the meibomian glands, reduced lipid secretion may
contribute to tear film instability and entry into the vicious circle of dry eye disease. The
prevalence of MGD is higher in Asian populations, ranging from 46% to 70%.
The management and treatment subcommittee of the International Workshop on MGD proposed a
treatment algorithm in which treatment is added depending on the severity of MGD. The
sequence of treatment addition is eyelid hygiene, eyelid warming and massage, artificial
lubricants, topical azithromycin, topical emollient lubricant, oral tetracycline derivatives,
lubricant ointment, and anti-inflammatory therapy.
Topical diquafosol solution has been used to treat dry eye because it increases fluid
secretion from conjunctival epithelial cells and mucin secretion from conjunctival goblet
cells via the P2Y2 receptor. Because P2Y2 receptor expression is observed in sebaceous cells
and ductal cells in the meibomian gland, diquafosol is expected to have some effects on
meibomian glands. it has been reported that use 3% diquafosol ophthalmic solution in patients
with obstructive MGD for more than 4 months. Ocular symptoms, lid margin abnormalities, the
superficial punctate keratopathy score, and the meibum grade were decreased, while the tear
breakup time, tear film meniscus area, and meibomian gland area were increased. These results
suggest that topical diquafosol therapy is effective for patients with obstructive MGD.
However, so far, no studies have reported the effect of DQS combined with eyelid hot compress
and eyelid gland massage for MGD.
Phase:
N/A
Details
Lead Sponsor:
Zhongshan Ophthalmic Center, Sun Yat-sen University