To Evaluate the Pharmacokinetic of Diacerein and Rhein After Maximum Use in Patients With Epidermolysis Bullosa (EB)
Status:
Completed
Trial end date:
2019-02-14
Target enrollment:
Participant gender:
Summary
A pharmacokinetic (PK) study in 16-20 EB subjects to be allocated to two cohorts. Cohort 1 to
include 8-10 subjects (ages 12 yrs and older); Cohort 2 to include 8-10 subjects (ages 6
months-11 yrs, inclusive). Cohort 2 only included subjects 4 yrs and older. Serial PK blood
sampling collected on Days 1 and 10. Analyses were performed to determine the concentrations
of diacerein and rhein.