To Study the Effectiveness and Safety of Niacin and a Topical Steroid Eye Drop to Treat Retinal Vein Occlusions

• Status: Completed
• Trial end date: 2016-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether Niacin, a B vitamin, may act as a vasodilator to encourage earlier formation of collateral blood vessels that may serve to bypass the obstructed vein in the eye. The topical steroid eye drops are aimed at reducing swelling in the retina, until the collateral vessels have a chance to develop.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Palo Alto Medical Foundation
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Niacin; Niacinamide; Nicotinic Acids; Ophthalmic Solutions; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate; Tetrahydrozoline

Criteria

Inclusion Criteria:

• Patients must be able to understand the study procedures, agree to participate, and give written consent.

• Patient must have central retinal vein occlusion, hemi-retinal vein occlusion or branch retinal vein occlusion.

• Patients must be able to follow the study medication regimen.

• Patients must agree to return for the once monthly eye exams.

• Patients must agree to have liver function tests performed on a regular basis.

• Patients must agree to have regular appointments with their Internist on an established basis.

Exclusion Criteria:

• Patients with active Gout, or high levels of Uric

• Patients may not be pregnant or lactating.

• The Principal Investigator reserves the right to exclude any patient who he feels will not make a good candidate.