Tocilizumab, Dexamethasone, Olanzapine, Hemodynamics, and Ventilation in Cardiac Surgery
Status:
Recruiting
Trial end date:
2027-12-01
Target enrollment:
Participant gender:
Summary
Open heart surgery, including coronary artery bypass grafting (CABG) and/or aortic valve
replacement (AVR) is associated with a significant risk of mortality.
This study is a randomized clinical trial with the purpose of investigating five different
interventions on the primary endpoint 'days alive and outside of hospital within 90 days'.
The interventions are:
- Tocilizumab vs. placebo administered after induction of anesthesia.
- Dexamethasone vs. placebo administered after induction of anesthesia.
- Olanzapine vs. placebo administered prior to anesthesia.
- A blood-flow targeted vs. a blod-pressure targeted hemodynamic strategy while the
patient is on cardio-pulmonary bypass (CPB)
- Low-tidal volume ventilation vs. no ventilation of the lungs while the patient is on CPB