Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease)

• Status: Completed
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose is to investigate tocilizumab administration in patients with moderately to severely or sight-threatening GO (Graves' ophthalmopathy) without response to treatment with corticoid intravenous pulses. Currently, these patients only have surgery as therapeutic alternative.

The principal aim of this study is to evaluate efficacy and safety of tocilizumab treatment in order to provide a better alternative to surgery for this patients.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital Clinico Universitario de Santiago
• Collaborator: Fundación Ramón Domínguez

Criteria

Principal Inclusion Criteria:

Patients diagnosed GO with CAS ≥ 4 and an index of severity, according EUGOGO guidelines,

1. moderately to severely or 2. sight-threatening GO, after receiving corticosteroid pulse treatment due to:

• Poor response to intravenous corticosteroid pulses Or

• Recurrence of the GO, after treatment with intravenous corticosteroids

Exclusion Criteria:

• Orbital decompression surgery needed immediately

• Active smoker

• Patients who could need treatment with radioactive iodine or thyroidectomy during the study

• Pregnant patient or patient who is planning to become pregnant during the study

• History of chronic recurrent or active infection

• History of intestinal ulceration or diverticulitis

• Patients with a history of chronic liver disease or liver disorders: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) above 5 times upper limit of normal (ULN)

• History of HIV, hepatitis C or hepatitis B Positive

• Neutrophil count < 0.5 × 109/L or a platelet count < 50×103/μL

• Simultaneous use or contraindications to the use of immunosuppressive agents

• A treatment with another investigational drug within four weeks of selection or five half-lives of study drug

• Cardiovascular or cerebrovascular disease clinically significant

• Uncontrolled diabetes mellitus

• Use of corticosteroids during four weeks before to inclusion period

• History of reactions or anaphylactic allergic severe human monoclonal antibodies, humanized or murine

• Uncontrolled pathologies, whose exacerbations are treated with corticosteroids