Overview

Tolerability Study of Xerecept® in Pediatric Patients

Status:
Terminated
Trial end date:
2013-03-01
Target enrollment:
0
Participant gender:
All
Summary
This study is being conducted to evaluate the safety and tolerability of Xerecept® in children with central nervous system tumors and to identify appropriate doses of Xerecept® to be used in subsequent pediatric clinical trials.
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Celtic Pharma Development Services
Treatments:
Corticotropin-Releasing Hormone
Criteria
Inclusion Criteria:

1. Have histologically confirmed primary, recurrent or metastatic cerebral tumors and
require chronic steroid dosing to manage symptoms of peritumoral brain edema (No
histological confirmation is required of optic pathway tumors or brain stem gliomas)

2. Have been taking dexamethasone (or equivalent) at a dose of ≥1 mg/day for a minimum of
14 days and have had a stable dose for at least 7 days.

3. Have one or more steroid-associated side effects at Screening (See Appendix A1 for a
list of qualifying events)

4. Capable of self-administration of subcutaneous injections twice daily or availability
of assistance from caregiver.

5. Karnofsky/Lansky performance status ≥ 40

6. Life expectancy of at least 6 months

7. Female subjects must not be pregnant or breast-feeding and, if of childbearing
potential, must use adequate methods of contraception during the study

10. Ability to provide written informed consent or, if unable to provide, have a legal
guardian or representative provide written informed

Exclusion Criteria:

1. Evidence of previous or current overt renal, hepatic or pulmonary diseases or active
uncontrolled infection

2. Subject and/or parent/guardian is unwilling or unable to comply with this protocol

3. Subject has a known history of allergy or intolerance to hCRF or other ingredients in
the Xerecept® solution (e.g., methionine, mannitol)

4. Subject has a known history of hepatitis C virus, hepatitis B surface, or human
immunodeficiency virus (HIV).