Tolerability and Lipid Lowering Effect of Weekly/Biweekly Crestor in Statin Intolerant Patients Treated With Zetia

• Status: Unknown status
• Trial end date: 2011-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Recently, research studies have shown that patients who have had trouble taking statins every day, are able to take statins if they take them only once or twice a week. The investigators are doing a research study which involves switching people who are taking ezetimibe to the statin Crestor once or twice a week and to see how ell Crestor lowers cholesterol and if it is tolerated.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bronx VA Medical Center
• Treatments: Ezetimibe; Rosuvastatin Calcium

Criteria

Inclusion Criteria:

• Patients with a history of intolerance to statins

• Patients currently receiving ezetimibe

• Patients willing and able to provide signed informed consent

Exclusion Criteria:

• Patients receiving a statin (Lipitor, Crestor, Lescol, Simvastatin, or Pravachol)

• Stroke, TIA, myocardial infarction, unstable angina, percutaneous coronary intervention, coronary artery bypass surgery, or major surgery within 3 months

• Cancer undergoing active treatment

• Creatinine clearance < 40 ml/minute

• Active liver disease or persistent elevation of SGOT or SGPT > 2 times the upper limit of normal level

• Participation in any clinical study within the last 30 days

• Drug addition or alcohol abuse within the past 6 months

• Use of cyclosporine within the last 3 months

• Use of gemfibrozil within the last month

• Patients unwilling or unable to provide informed consent

• Patients with poor compliance

• Women of childbearing potential

• History of rhabdomyolysis due to statins