Tongjiang Series Prescription Combined With PPIs Descending Ladder Withdrawal in Treating Nonerosive Reflux Disease
Status:
Recruiting
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
Nonerosive Reflux Disease (NERD) is a common refractory gastrointestinal disease. Proton Pump
Inhibitors (PPIs), the preferred drug, have poor response, single target and poor acid
inhibition effect in some patients in clinical application. Long-term use of PPI can lead to
many side effects, even dependency. The main Traditional Chinese Medicine (TCM)syndrome types
of NERD are liver-stomach depression-heat syndrome, spleen deficiency damp-heat syndrome and
cold-heat complicated syndrome. TCM syndrome differentiation treatment has the advantages of
overall regulation and individualized treatment. The purpose of this study is to evaluate the
safety and efficacy advantages of syndrome differentiation series prescription combined with
PPIs descending ladder withdrawal in the treatment of patients who use PPIs for a long time
that can not stop, and to solve the problems of multiple side effects and dependency caused
by long-term use of PPIs.
Phase:
Phase 3
Details
Lead Sponsor:
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Collaborators:
Guangdong Provincial Hospital of Traditional Chinese Medicine Liuzhou Hospital of Traditional Chinese Medicine The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Traditional Chinese Medicine Hospital of KUNSHAN Wuhan No.1 Hospital