Topical 5-Fluorouracil Effervescent Powder in the Treatment of Vitiligo
Status:
Not yet recruiting
Trial end date:
2023-03-15
Target enrollment:
Participant gender:
Summary
A novel approach for 5-Fluorouracil delivery based on a solid effervescent formulation is
proposed . 5-Fluorouracil is water soluble (~50mg/ml) and therefore has been used for the
development of novel topical formulations including nano and microparticles intended for skin
targeting. After hydration 5-Fluorouracil could form a complex, a suspension or even be
formulated to generate effervescence. In effervescent technology, gas bubbles occur from the
liquid after chemical reaction between alkali salts and organic acids (mainly citric or
tartaric. Due to liberation in CO2 gas, the dissolution of drug in water is enhanced. The aim
of this study is the development and clinical evaluation of topical 5-florouracil
effervescent powder formulation in the treatment of vitiligo.