Topical Anesthesia and Intra-arterial Chemotherapy for Retinoblastoma
Status:
Withdrawn
Trial end date:
2020-12-01
Target enrollment:
Participant gender:
Summary
The objective of this study is to use local topical anesthesia to numb the sensory input,
captured by branches of the Trigeminal nerve found on the skin in and around the eye, to
decrease a hemodynamic reflex seen during placement of a catheter for intra-arterial
chemotherapy (IAC) for eye tumors in children. This Trigeminal-cardiac reflex brings about
hemodynamic instability during general anesthesia.
Normally, one could block this sensorial input with ophthalmic peribulbar placement of local
anesthetics, but these eyes have malignant growth and invasive procedures may cause more
harm. The investigators are aiming to numb the sensory branches of the trigeminal nerve
non-invasively and observe for any decrease in these events.