There is a certain group of patients that has chronic rhinosinusitis that has continued even
with treatment including saline and steroid nasal irrigations as well as oral steroids and
antibiotics and surgery.
In these patients, the use of topical antibiotic nasal rinses may be of benefit to their
disease. The use of topical antibiotic nasal rinses is commonly used as standard of care
already throughout the country for refractory chronic rhinosinusitis including here at the
Mayo Clinic. Our pharmacy has compounded this medication for this specific purpose. As such,
this study is not aimed at a 'novel medication', but rather to investigate the efficacy of a
medication already in common use but without great evidence.
The investigators are doing this research study to find out if patients develop antibiotic
resistant organisms after the use of topical antibiotics in the treatment of chronic
rhinosinusitis.
In addition, this study will look at the effects of topical antibiotics on patient symptoms
as measured by a patient survey called the Sino-Nasal Outcomes Test (SNOT-22) and in-office
an exam of the inside of their nose, including with a scope (a camera on the end of a long
tube).