Topical Application of Imiquimod Gel at Different Concentrations in Actinic Cheilitis

• Status: Recruiting
• Trial end date: 2020-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Actinic cheilitis is a potentially malignant lesion on the lower lip, which can progress to more serious illnesses such as cancer if not treated. Usually treatment of this condition is only based on clinical appearance, but there is no established cure treatment. Topical imiquimod is a medicine indicated for the treatment of skin diseases, but it has not yet been proven to treat actinic cheilitis. In this research, the investigator's aim is to evaluate the response to actinic cheilitis treatment with the current standard treatment compared to high and low concentration imiquimod topical formulations.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hospital de Clinicas de Porto Alegre
• Collaborator: Federal University of Rio Grande do Sul
• Treatments: Imiquimod; Sunscreening Agents

Criteria

Inclusion Criteria:

• Individuals with clinical and histopathological diagnosis of actinic cheilitis;

• No previous lip treatment with Imiquimod.

Exclusion Criteria:

• Present lesions suspected of squamous cell carcinoma of the lip.

• Previous history of lip cancer treatment.

• Prior treatment other than standard treatment.

• History of allergic reactions to imiquimod or any other component of the formulas.