Rationale: CBD is commonly being used as an over-the-counter treatment for musculoskeletal
pain; however, no clinical trial has been performed to establish efficacy of CBD in humans
for musculoskeletal pain.
Hypothesis: CBD is more effective than placebo for relieving pain and improving
patient-reported outcomes for musculoskeletal pain.
Study Design: The study design with be a double-blind, randomized controlled trial with
crossover. Treatment will be blinded to the subjects and investigators. Patients will be
randomly assigned 2 weeks of the CBD or control and then crossover to the other condition for
2 additional weeks. Patients will apply the CBD or control cream to the affected area twice
daily (approximately every 12 hours) for 1 hour. Subjects will be advised to observe for
physiologic changes, skin changes, or other adverse effects.