The purpose of this study is to see if curcumin can suppress HPV infection in women with
low-grade squamous intraepithelial lesions (LSIL) disease or treated high-grade squamous
intraepithelial lesions (HSIL) disease. This study plans to explore the effect of curcumin as
a potential medical treatment in HIV-uninfected and infected women with mild precancerous
lesions of the cervix or recently treated high-grade precancerous lesions at risk for
persistent HPV infection. About 200 women with low-grade precancerous lesions of the cervix
or recently treated high-grade precancerous lesions will be enrolled to either insert 2000 mg
of curcumin capsules in their vagina once a week or placebo after undergoing colposcopy or
loop electrosurgical excision procedure (LEEP). They will have a repeat visit in 6 months
where they will undergo a Pap smear and HPV test to determine if there are higher rates of
HPV clearance after curcumin administration. If HPV is present or the Pap smear is abnormal,
patients will then undergo colposcopic examination to evaluate cervical histology.