Topical Cyclosporine-A for Management of Epiphora

• Status: Completed
• Trial end date: 2020-11-01
• Target enrollment: 0
• Participant gender: All

Summary

to investigate the clinical outcomes and tolerances of Cyclosporine A (CsA) in treating epiphora in eyes with acquired punctum stenosis

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Farwaniya Hospital
• Treatments: Lubricant Eye Drops

Criteria

Inclusion Criteria:

• Adult patients of either sex

• had a diagnosis of epiphora that persisted more than three months both indoors and outdoors

• grade 0 punctal stenosis

• did not adequately respond to artificial tears, topical corticosteroids and topical antibiotics or in whom corticosteroids were discontinued due to their side effects.

Exclusion Criteria:

• congenital punctal obstruction

• edematous puncti

• allergic conjunctivitis

• history of dacryocystitis,

• inflammatory systemic diseases

• any previous chemotherapy treatment, and local irradiation.

• other causes of epiphora, lid laxity, entropion, and ectropion

• lid malposition, canalicular or nasolacrimal sac or duct obstruction

• previous eyelid or lacrimal drainage surgery

• untreated conjunctivitis or blepharitis