Topical Gentamicin Cream Versus Alternating Gentamicin and Mupirocin Cream in Peritoneal Dialysis
Status:
Unknown status
Trial end date:
2014-10-01
Target enrollment:
Participant gender:
Summary
Catheter-related infection, namely exit site infection and peritonitis, is the commonest
complication of peritoneal dialysis. This complication causes significant morbidity and
mortality in patients requiring peritoneal dialysis. Topical application of mupirocin 2%
cream was first proven to be effective in reduction of staphylococcus-related catheter
infection in 1990s. Subsequent randomized trial published in 2005 showed that gentamicin
cream was superior to mupirocin 2% cream in reducing both Gram's positive and Gram's negative
related catheter infection. However, a retrospective report published in 2007 puts the use of
prophylactic antibiotic cream into a question. It reported an emergency of non-tuberculous
mycobacterial infection in a dialysis center in Hong Kong after practising prophylactic
application of gentamicin cream at the catheter exit site. The following prospective,
randomized and open-label study aims to find out an optimal regimen of topical antibiotic
prophylaxis in patients requiring peritoneal dialysis.