Topical Hyaluronic Acid and Recurrent Aphthous Stomatitis.

• Status: Completed
• Trial end date: 2020-01-20
• Target enrollment: 0
• Participant gender: All

Summary

This study was conducted to estimate the hypothesis that the topical hyaluronic acid mouthwash have no role in the treatment of recurrent aphthous stomatitis

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cairo University
• Treatments: Chlorhexidine; Hyaluronic Acid

Criteria

Inclusion Criteria:

The inclusion criteria were as follows:

• Age 18-30 years.

• Minimum of 2 years of RAS history, with active ulcer less than 48 hours of recurrent aphthous stomatitis.

Exclusion Criteria:

• known history of hypersensitivities to Chlorhexidine or hyaluronic acid.

• Use of any medication as a treatment for the present active ulcer.

• Smoking and presence of systemic diseases such as Behçet disease, anemia, Crohn's disease, ulcerative colitis, acquired immune deficiency syndrome, and liver or kidney disease.

• Pregnant or breast-feeding women.

• Stomach ulcer, duodenal ulcer, and inflammation of the stomach or the esophagus.

• Treatment with systemic nonsteroidal anti-inflammatory drugs, systemic steroids or other immune modulatory agents, oral antihistamines, or systemic antibiotics in the previous 3 months.