Topical Metformin Emulgel VS Salicylic Acid Peeling in Treatment of Acne Vulgaris

• Status: Not yet recruiting
• Trial end date: 2023-09-10
• Target enrollment: 0
• Participant gender: All

Summary

Acne Vulgaris (AV ) is a common skin disorder worldwide, affecting all ages and races, considered as a long term chronic inflammatory disease of the skin.It affects nearly 85% of adolescents and about 30% of adults which is known as post- adolescent acne that often occurs in individuals aged 25 years or older particularly women.

Acne lesions, which may be papules, pustules, or nodules commonly affecting face, chest and back therefore acne patients may suffer from emotional distress due to its chronicity and potential outcomes which include physical scars and persistent hyperpigmentation.

The pathophysiology of AV involves four factors: abnormal follicular keratinization, hyperseborrhea, Cutibacterium acnes proliferation in the pilosebaceous unit and inflammatory mediators released into the skin.

Diet is considered to be one of the main factors influencing the induction and aggravation of acne, though this is still debatable. Previous researches have focused on glycemic load, and hyperinsulinemia which lead to an increase in the concentration of insulin-like growth factor (IGF-1), which has been reported to affect androgen metabolism and lipogenesis Additionally, IGF-1 has been shown to upregulate inflammatory cytokines. A correlation between the severity of acne and the level of serum IGF-1 has also been reported. Previous clinical studies showed that a low glycemic diet can decrease both the size of the sebaceous gland and the number of inflammatory lesions

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Metformin; Mitogens; Salicylates; Salicylic Acid

Criteria

Inclusion Criteria:

• Both males and females will be included.

• Patients older than 18 years of age.

• Patients with mild and moderate AV.

• Patients with Fitzpatrick skin type III, IV and V.

Exclusion Criteria:

• Severe acne.

• Patients under treatment with contraceptive pills or received any kinds of systemic or topical acne medication in the last 2 months (isotretinoin, antibiotics, topical products) or corticosteroid, lithium, growth hormone, systemic metformin, vitamin B12, whey proteins, and estrogenic-progestogens.

• History of hypertrophic/keloid scar formation.

• Pregnancy and lactation.

• Recurrent herpes infection.

• Subjects with diseases that affect IGF-1 levels such as diabetes, metabolic syndrome, and acromegaly.

• Conditions that affect liver or thyroid function, celiac disease and inflammatory bowel diseases.