Topical Metformin Emulgel VS Salicylic Acid Peeling in Treatment of Acne Vulgaris
Status:
Not yet recruiting
Trial end date:
2023-09-10
Target enrollment:
Participant gender:
Summary
Acne Vulgaris (AV ) is a common skin disorder worldwide, affecting all ages and races,
considered as a long term chronic inflammatory disease of the skin.It affects nearly 85% of
adolescents and about 30% of adults which is known as post- adolescent acne that often occurs
in individuals aged 25 years or older particularly women.
Acne lesions, which may be papules, pustules, or nodules commonly affecting face, chest and
back therefore acne patients may suffer from emotional distress due to its chronicity and
potential outcomes which include physical scars and persistent hyperpigmentation.
The pathophysiology of AV involves four factors: abnormal follicular keratinization,
hyperseborrhea, Cutibacterium acnes proliferation in the pilosebaceous unit and inflammatory
mediators released into the skin.
Diet is considered to be one of the main factors influencing the induction and aggravation of
acne, though this is still debatable. Previous researches have focused on glycemic load, and
hyperinsulinemia which lead to an increase in the concentration of insulin-like growth factor
(IGF-1), which has been reported to affect androgen metabolism and lipogenesis Additionally,
IGF-1 has been shown to upregulate inflammatory cytokines. A correlation between the severity
of acne and the level of serum IGF-1 has also been reported. Previous clinical studies showed
that a low glycemic diet can decrease both the size of the sebaceous gland and the number of
inflammatory lesions