Topical Methotrexate Microemulsion in the Treatment of Plaque Psoriasis
Status:
Not yet recruiting
Trial end date:
2022-10-01
Target enrollment:
Participant gender:
Summary
- Psoriasis is a chronic relapsing dermatological disease which often necessitates a
long-term therapy and occurs in a significant percent of the population . It affects the
skin and sometimes the nails and joints of patients .
- Psoriatic patients are frequently categorized into two groups: mild or moderate to
severe psoriasis, depending on the clinical severity of the lesions, the percentage of
affected body surface area, and patient quality of life .
- Topical drug therapy is the cornerstone in the treatment of mild to moderate psoriasis.
It offers a direct targeting of affected skin by avoiding systemic adverse events .
- Several topical therapies are available for the treatment of psoriasis such as topical
steroid , topical vitamin D3 analogues (calcipotriol),tar, anthraline, topical
tacrolimus (a non-steroidal calcineurin inhibitor) and tazarotene (a third-generation
retinoid) . However, they do not provide an adequate response owing to the inadequate
percutaneous absorption and poor patient compliance caused by greasiness and stickiness
of some formulations, and some patients even remain untreated .
- So that, patient satisfaction with available topical treatments remains modest .