Overview

Topical Methotrexate Microemulsion in the Treatment of Plaque Psoriasis

Status:
Not yet recruiting

Trial end date:
2022-10-01

Target enrollment:
0

Participant gender:
All

Summary

- Psoriasis is a chronic relapsing dermatological disease which often necessitates a long-term therapy and occurs in a significant percent of the population . It affects the skin and sometimes the nails and joints of patients . - Psoriatic patients are frequently categorized into two groups: mild or moderate to severe psoriasis, depending on the clinical severity of the lesions, the percentage of affected body surface area, and patient quality of life . - Topical drug therapy is the cornerstone in the treatment of mild to moderate psoriasis. It offers a direct targeting of affected skin by avoiding systemic adverse events . - Several topical therapies are available for the treatment of psoriasis such as topical steroid , topical vitamin D3 analogues (calcipotriol),tar, anthraline, topical tacrolimus (a non-steroidal calcineurin inhibitor) and tazarotene (a third-generation retinoid) . However, they do not provide an adequate response owing to the inadequate percutaneous absorption and poor patient compliance caused by greasiness and stickiness of some formulations, and some patients even remain untreated . - So that, patient satisfaction with available topical treatments remains modest .

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Assiut University

Treatments:

Methotrexate

Criteria

Inclusion criteria:

1. Thirty patients with mild psoriasis will be recruited from the Dermatology Outpatient
Clinic, Assiut University Hospital.

2. The diagnosis will be based upon the clinical characteristics of plaque psoriasis.

3. Patients will be included after they have stopped any systemic therapy for at least 8
weeks and topical therapy for at least 2 weeks.

Exclusion Criteria:

1. Patients having cardiovascular, renal or liver diseases.

2. Patients with photosensitive or psychological disorders or immunodeficient patients.

3. Pregnant or lactating woman