Topical Pentoxifylline; Metformin Versus Betamethasone in the Treatment of Alopecia Areata.

• Status: Not yet recruiting
• Trial end date: 2024-10-01
• Target enrollment: 0
• Participant gender: All

Summary

To compare the efficacy and safety of topical pentoxifylline 2% gel and topical metformin 10% gel versus topical betamethasone valerate 0.1% cream, in treatment of patchy alopecia areata.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Betamethasone; Betamethasone benzoate; Betamethasone sodium phosphate; Betamethasone Valerate; Betamethasone-17,21-dipropionate; Metformin; Pentoxifylline

Criteria

Inclusion Criteria:

• A clinical diagnosis of patchy alopecia areata of scalp involving < 50% of the total scalp confirmed by dermoscopy of both males and females.

• patients age between 6 and 60 years old.

Exclusion Criteria:

• Alopecia totalis and alopecia universalis.

• Cicatricial alopecia.

• Other causes of hair loss such as; endocrine or immunological disease.

• Skin disease in the affected area.

• Hypersensitivity or allergy to any of the treatment products used.

• Patient using treatment (topical or systemic) for alopecia areata in the last 2 months.

• Systemic administration of any of the three test drugs (pentoxifylline, metformin and steroids).

• Pregnant and lactating females.