This is an investigator-initiated, proof of concept, open study to assess efficacy of a
topical Ruxolitinib in subjects with Chronic Hand Dermatitis (CHD). The study will be
conducted at the University of Rochester Medical center, Dermatology Department - Rochester,
NY. Qualified and enrolled subjects (see Inclusion/Exclusion criteria) will be required to
come to URMC Dermatology Clinic for at least five visits.