Topical Steroid Treatment for Eosinophilic Esophagitis
Status:
Completed
Trial end date:
2010-04-01
Target enrollment:
Participant gender:
Summary
This was a randomized controlled trial of swallowed fluticasone vs. placebo for eosinophilic
esophagitis. Eosinophilic esophagitis is an inflammatory condition in which the wall of the
esophagus becomes filled with large numbers of eosinophils, a type of white blood cell.
Patients who have this condition have difficulty in swallowing (dysphagia) solid food.
Prior to treatment the patients had biopsies of their esophagus and took questionnaires
regarding their symptoms. Treatment was given for 6 weeks, after which biopsies were taken
from the esophagus to measure any changes in the tissue from before treatment. The primary
endpoint was improvement in dysphagia as measured by the validated Mayo Dysphagia
Questionaire. Secondary outcomes included partial symptom response, and histologic (tissue)
response to treatment.