Topiramate and Cerebrovascular Response in Migraineurs

• Status: Completed
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the effect of topiramate on cerebrovascular reactivity and mean flow velocity to photic stimulation in migraineurs.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: SMG-SNU Boramae Medical Center
• Treatments: Topiramate

Criteria

Inclusion Criteria:

• aged 18 to 65 years

• newly-diagnosed patients with migraine without aura (International Headache Society classification)

• symptom frequency (at least 2 episodes of migraine attack/month)

Exclusion Criteria:

• prior use of preventive medication

• patients with cardiovascular risk factors (hypertension, diabetes, hyperlipidemia, smoking)

• patients who take antihypertensive agent or antidepressant

• patients who were pregnant, breast-feeding or actively smoking

• patients with neurological or cerebrovascular diseases