Topography Staging and Dual Phase Image Quantification of Tau PET in Cognitive Impairment Subjects
Status:
Recruiting
Trial end date:
2023-09-30
Target enrollment:
Participant gender:
Summary
A second-generation tau PET image tracer 18F-PM-PBB3 (APN-1607 or MNI-958) has been developed
by National Institute of Radiological Sciences. The new tracer solved the off-target binding
issue. This study will evaluate new quantitative methods with PMPBB3, by utilized dual phase
scanning protocol to extract blood flow and Tau protein binding information, to evaluate
appropriate reference brain regions, to improve the normalization efficiency of brain
imaging, and to establish a brain template image analysis platform.