Total Knee Replacement TIVA With Robotic Arm Assisted
Status:
Not yet recruiting
Trial end date:
2021-05-31
Target enrollment:
Participant gender:
Summary
Total knee replacement (TKR) is a commonly performed surgical procedure, and is associated
with moderate to severe acute postoperative pain. Poor acute postoperative pain control has
been associated with increased morbidity, prolonged recovery, reduced patient satisfaction
and chronic post-surgical pain. Multimodal analgesia in the context of enhanced recovery
after surgery programs is advocated for conventional total knee replacement. More recently,
robotic arm assisted total knee replacement has been introduced. TKR is most commonly
performed under spinal anaesthesia or general anaesthesia using inhalational agents or
propofol total intravenous anaesthesia (TIVA). It is unclear which is the best anaesthetic
technique for postoperative analgesia. There has been no head to head trial comparing these 3
anaesthetic techniques in the context of modern multimodal and enhanced recovery after
surgery (ERAS) protocols for conventional and robotic arm assisted TKR. Propofol TIVA may
reduce postoperative pain and opioid consumption after surgery, but the overall evidence is
still controversial. Whether propofol TIVA provides better analgesia compared to inhalational
anaesthesia for TKR is not known. A prospective, randomized controlled trial providing head
to head comparisons between general anaesthesia with propofol TIVA, inhalational anaesthesia,
and spinal anaesthesia under is indicated.
In this study, we plan to perform a randomized controlled trial to compare postoperative
analgesia after robotic arm assisted TKR in three commonly used anaesthetic techniques: 1)
spinal anaesthesia (SA), 2) general anaesthesia with inhalational anaesthesia (GAS), 3)
general anaesthesia with propofol TIVA (TIVA). This clinical trial will be conducted within
the framework of modern multimodal analgesic and enhanced recovery after surgery pathways.
In this study, we plan to perform a randomized controlled trial to compare postoperative
analgesia after TKR in three commonly used anaesthetic techniques: 1) spinal anaesthesia
(SA), 2) general anaesthesia with inhalational anaesthesia (GAS), 3) general anaesthesia with
propofol TIVA (TIVA). This clinical trial will be conducted within the framework of modern
multimodal analgesic and enhanced recovery after surgery pathways.