Overview

Total Neoadjuvant Treatment Plus SHR1210 for High-risk Rectal Cancer and Biomarker Screening Base on Neoantigen

Status:
Recruiting
Trial end date:
2022-04-01
Target enrollment:
0
Participant gender:
All
Summary
This study is designed to test the efficacy and safety of Total Neoadjuvant Treatment plus SHR1210(an anti-PD-1 Inhibitor) for High-risk locally advanced Rectal Cancer, Meanwhile, screening effective Biomarker base on neoantigen.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Beijing Cancer Hospital
Treatments:
Capecitabine
Oxaliplatin
Criteria
Inclusion Criteria:

- Age ≥ 18 years and ≤70 years.

- ECOG Performance status 0-1.

- Histologically confirmed diagnosis of adenocarcinoma of the rectum.

- The distance from down verge of tumor to anal-rectal junction (ARJ) ≤8cm, or ≤12 cm
based on sigmoidoscopy.

- Clinical Stage T3c, T3d, T4a or T4b, or EMVI (+) or mrN2 or MRF (+) based on MRI.

- No evidence of distant metastases.

- No prior pelvic radiation therapy.

- No prior chemotherapy or surgery for rectal cancer.

- No active infections requiring systemic antibiotic treatment.

- No systemic infection requiring antibiotic treatment.

- No immune system disease.

- ANC > 1.5 cells/mm3, HGB > 9.0 g/dL, PLT > 100,000/mm3, total bilirubin≤ 1.5×ULN, AST≤
2.5×ULN, ALT ≤ 2.5×ULN.

- Serum creatinine is within 1.5 times the physiological range, creatinine clearance
rate≥50 ml/min

- Patients with controllable hypertension were included.

- Patients who did not receive anticoagulant therapy: INR, aPTT is required to be within
the 1.5 times the physiological range;Patients who receive anticoagulant therapy: INR,
aPTT is required to be within the physiological range.

- FT3, FT4, TSH are Normal or abnormal without clinical significance.

- ECG examination is Normal or abnormal without clinical significance; Echocardiography
shows that LVEF>50%.

- Patients must read, agree to, and sign a statement of Informed Consent prior to
participation in this study.

- Patients show good adherence, follow -up on time. It is recommended that all patients
provide tumor tissue samples (preferably fresh tissue samples) for pathological
genetic testing prior to enrollment.

- Fertile men or women with potential for pregnancy must use highly effective
contraception throughout the trial. And continue contraception for 12 months after
treatment ends.

Exclusion Criteria:

- Recurrent rectal cancer.

- Anticipated unresectable tumor after neoadjuvant treatment.

- Patients with a history of a prior malignancy within the past 5 years, except for
adequately treated basal cell or squamous cell skin cancer.

- Patients with a history of any arterial thrombotic event within the past 6 months.
This includes angina (stable or unstable), MI, TIA, or CVA.

- Other Anticancer or Experimental Therapy.

- Women who are pregnant or breast-feeding.

- Patients with any other concurrent medical or psychiatric condition or disease which
would make them inappropriate candidates for entry into this study.

- Patients with a history of anti-PD-1, anti-PD-L1, anti-PD-L2 or CEGFR TKI therapy.

- Patients underwent major surgery or had not recovered from the side effects of this
surgery, received a vaccine, received immunotherapy within 4 weeks before the first
use of the study drug, and received radiotherapy within 2 weeks.

- Patients who received hematopoietic stimulating factors therapy, such as G-CSF and
erythropoietin, within 1 week before the first administration of the study drug.

- Patients are allergic to study medication and its ingredients.

- Patients have active lung disease (such as interstitial pneumonia, pneumonia,
obstructive pulmonary disease, asthma) or active tuberculosis.

- Patients have any uncontrollable clinical problems, including but not limited to:

1. Persistent or severe infection.

2. Hypertension that can't be effectively controlled by drugs( blood pressure
reading of 150 over 90).

3. Uncontrolled diabetes

4. Heart disease (Class III / IV congestive heart failure or cardiac block as
defined by the New York Heart Association)

5. Patient has or is suspected of having an autoimmune disease,Such as pituitary
inflammation, colitis, hepatitis, nephritis, hyperthyroidism, hypothyroidism,
etc.

- Patients have other serious, acute or chronic diseases or have abnormal test results,
and the investigator judges that this may increase the patient's risk of participating
in the trial or interfere with the results.