Toulouse Male Long Term Bed Rest 2001-2002

• Status: Completed
• Trial end date: 2003-06-01
• Target enrollment: 0
• Participant gender: Male

Summary

Microgravity during space flight induces physiological changes that affect astronauts' health and performance. Space flight simulations such as prolonged bed rest can mimic some of these changes and provide study conditions that are more accessible than during space flight. The European Space Agency, ESA together with the French national space agency, CNES and the Japanese national space agency, NASDA are performing extensive studies using long duration bed rest.

Previous studies including several long and short term bed rest campaigns have yielded significant medical data on the physiological changes induced by space flight. These data can be used to study the effect of countermeasures, methods helping to prevent these physiological changes.

The long duration bed rest, lasting 3 months undertakes a variety of investigations involving 28 subjects. This study focuses on countermeasures, studying the effect of a bone tissue stabilisation medication and resistive exercises to determine their suitability for use during long duration stays on ISS.

The physiological changes recorded during space flight and bed rest mimic those observed in some diseases and in the aging process. Significant clinical applications are expected as a direct result of this experiment and future equivalent studies.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre National d'Etudes Spatiales
• Collaborators: European Space Agency; National Space Development Agency, Japan

Criteria

Inclusion Criteria:

• Healthy male volunteer , citizen of the European Community.

• Age 25 to 45,

• Non smokers,

• No alcohol, no drug dependence and no medical treatment,

• Height 165 cm to 185 cm,

• No overweight nor excessive thinness. BMI (weight Kg/ height m2) between 20 and 27,

• No personal nor family past record of chronic or acute disease which could affect the physiological data and/or create a risk for the subject during the experiment,

• Subject to be covered by a Social Security system,

• Free of any engagement during four consecutive months.

Exclusion Criteria:

• Having given blood (more than 300ml) in a period of three months or less before the start of the experiment,

• Subject already participating in a clinical research experimentation,

• Poor tolerance to blood sampling,

• Past record of orthostatic intolerance,

• Cardiac rhythm disorders,

• Allergies,

• Intensive sport training,

• Fractures or tendon laceration since less than one year,

• Chronic back pains,

• Past records of thrombophlebitis,

• Presence of metallic implants,

• Special food diet,

• Sleep disorders :Lark and owl type,Subject sleeping more than 10 hours or less than 5 hours,

• Photosensitive epilepsy.