Toward a Computationally-Informed, Personalized Treatment for Hallucinations
Status:
Recruiting
Trial end date:
2022-03-01
Target enrollment:
Participant gender:
Summary
Auditory hallucinations are among the most distressing aspects of psychotic illness, and
between 10 and 30% of people with hallucinations do not respond to antipsychotic medications.
The authors have used computational modeling of behavior to link brain activity to
development of auditory hallucinations in the hope of guiding new treatment development. The
proposed studies take the first step toward individualized treatment approaches to
hallucinations by attempting causal, pharmacological manipulation of relevant model
parameters underlying these phenomena.