Toward a Safe and Reachable Preventive Therapy for LTBI: a Multicenter Randomized Controlled Study in Taiwan

• Status: Unknown status
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Background:

Tuberculosis (TB) remains the most important infectious disease in the world. Keys to successful control of TB is rapid diagnosis, prompt treatment, as well as effective preventive therapy for contacts with latent TB infection (LTBI). Current methods for the diagnosis of LTBI are tuberculin skin test (TST) and interferon-gamma release assay (IGRA). For preventive therapy, the recommended regimens include daily isoniazid for 9 months and daily rifampicin for 4 months. By incorporating long-acting rifapentine, a new regimen combining weekly rifapentine and high-dose isoniazid for a total of 12 doses has been proven of equal potency and toxicity. However, the treatment completion rate is much higher in weekly treatment for 3 months than daily treatment for 9 months. It is reasonable that using rifapentine-based preventive therapy can markedly increase the completion rate. However, study is lacking, especially in Asia, the high endemic area of TB.

With the effort of all health care workers and public health personnel, the incidence of TB in Taiwan has gradually declined in recent 10 years. In order to maintain the trend of decreasing in incidence, preventive therapy for LTBI become more and more important. However, which is the best preventive regimen for LTBI is still unknown. Therefore, we conduct the prospective randomized multicenter studies to compare the treatment completion rate of two regimens in Taiwan. The first regimen is daily isoniazid for 9 months. The second is weekly rifapentine plus high-dose isoniazid for 3 months.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Taiwan University Hospital
• Treatments: Isoniazid; Rifampin; Rifapentine

Criteria

Inclusion criteria:

• Household contacts of TB or TB contacts in schools or densely-populated institutes

• Age ≥12 year-old

• Index case having smear-positive pulmonary TB

• Contact with index case for >8 hours within single day or >40 hours within total transmissible period

• TST ≥10 mm within one month

• Born in 1986 or after (not applicable in the National Taiwan University Hospital Hsin-Chu branch and Chang-Hua Hospital)

Exclusion Criteria:

• Clinical or radiographic evidence of active TB

• Index case having culture-negative pulmonary TB

• Index case having Isoniazid or Rifampin-resistant TB

• Receiving medications with significant interactions with Isoniazid, Rifampin, or Rifapentine

• Allergy to Isoniazid, Rifampin, or Rifapentine

• Sero-positive for hepatitis B virus (HBV) or hepatitis C virus (HCV) infection

• Documented liver cirrhosis

• Human immunodeficiency virus (HIV) infection

• Receiving immunosuppressants

• Receiving biological agents

• Hemoglobin <8 g/dL

• Neutrophil <750000 /mL

• Total bilirubin >2.5 mg/dL

• Aspartic transaminase (AST) or alanine transaminase (ALT) >2 folds of upper limit of normal (ULN)

• Pregnant or breast-feeding

• Life expectancy <3 years