Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery

• Status: Completed
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate if the anesthetics propofol and isoflurane can damage DNA, induce apoptosis, change expression of genes related to apoptosis and DNA repair and change cytokines profile in patients submitted to elective surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: UPECLIN HC FM Botucatu Unesp
• Collaborator: Fundação de Amparo à Pesquisa do Estado de São Paulo
• Treatments: Anesthetics; Isoflurane; Propofol

Criteria

Inclusion Criteria:

• patients in good health American Society of Anesthesia status physical I

• elective minor surgery

• general anesthesia

Exclusion Criteria:

• smokers

• alcoholics

• previous medication or radiation