Training Effects on Skeletal Muscle Fatty Acid Metabolism
Status:
Completed
Trial end date:
2014-01-01
Target enrollment:
Participant gender:
Summary
We are interested in how skeletal muscle processes fat and how this may affect insulin
resistance. This is an important question since insulin resistance predates and predicts type
2 diabetes. We know that if pharmaceutical grade fat is infused into people, they develop
insulin resistance. Likewise, we would like to infuse pharmaceutical grade fat into trained
subjects, believing that trained subjects will have less insulin resistance, less decline in
muscle energy function, and less accumulation of fat metabolites than untrained subjects. For
comparing the effects of the pharmaceutical grade fat infusion, we will also have a group of
trained and untrained subjects given a control (glycerol) infusion. Glycerol is basically the
same as pharmaceutical grade fat infusion without the fat component.
Phase:
N/A
Details
Lead Sponsor:
University of Minnesota University of Minnesota - Clinical and Translational Science Institute