Tramadol to Reduce Opioid Withdrawal Symptoms

• Status: Completed
• Trial end date: 2005-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Individuals with opioid addiction often experience serious withdrawal symptoms that may make relapse unavoidable. Tramadol, a medication that is currently used to treat pain caused by chronic conditions such as cancer or joint pain, may also be effective at reducing opioid withdrawal symptoms. This study will evaluate the effectiveness of tramadol at reducing withdrawal symptoms in individuals addicted to opioid drugs.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute on Drug Abuse (NIDA)
• Treatments: Morphine; Naloxone; Tramadol

Criteria

Inclusion Criteria:

• Meets DSM-IV diagnostic criteria for opioid dependence

• Is in good physical health

• Qualifies for treatment with opioid agonist therapy (e.g., methadone)

• If female, must have a negative pregnancy test prior to study entry

Exclusion Criteria:

• Evidence of significant medical illness (e.g., insulin dependent diabetes mellitus)

• Evidence of significant psychiatric illness (e.g., schizophrenia)

• Currently seeking treatment for substance abuse

• Pregnant or breastfeeding