Overview

Tranexamic Acid Effect on Digit Function Following Primary Repair of Traumatic Digit Flexor Tendon Injuries

Status:
Not yet recruiting
Trial end date:
2023-03-01
Target enrollment:
0
Participant gender:
All
Summary
This study evaluates the effect of pre-operative treatment with IV Tranexamic Acid on post-operative digit function, in patients that underwent surgical repair of traumatic zone 1 or zone 2 digit flexor tendon tear.
Phase:
Early Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Rabin Medical Center
Treatments:
Tranexamic Acid
Criteria
Inclusion Criteria:

- Patients that will undergo surgical repair of traumatic zone 1 or zone 2 digit flexor
tendon tears

Exclusion Criteria:

- Age < 18

- Pregnant Women

- Patients that presented 3 weeks or later after the injury

- Medical history positive for Rheumatic disease

- Current active treatment with anti-coagulation medications

- Injury to more than one finger

- Presence of a fracture in the affected finger

- Presence of a nerve injury in the affected finger that won't enable early use and
activation in early rehabilitation protocol

- Mangled extremity injury, degloving injury or other soft tissue injuries that won't
enable primary closure of skin

- Previous tear of the affected tendon

- Degenerative tear of flexor tendon

- Tendon tear secondary to infection

- Previous injuries to contralateral side causing dysfunction and/or decreased fingers'
range of motion

- Contraindications to Tranexamic acid treatment:

- Known hypersensitivity to tranexamic acid or to any other ingredient of the
preparation.

- Patients with thromboembolic disease.

- Patients with active intravascular clotting.

- Severe renal failure because of risk of accumulation.

- Patients with subarachnoid hemorrhage

- Patients with acquired defective color vision