Tranexamic Acid and Depot-Medroxyprogesterone Acetate for Perimenopausal Irregular Uterine Bleeding
Status:
Recruiting
Trial end date:
2022-05-01
Target enrollment:
Participant gender:
Summary
Abnormal uterine bleeding is a symptom and not a disease. It is one of the most frequently
encountered complaints in gynecologic practice. It accounts for more than 70% of all
gynecological consultations in the peri- and post-menopausal age group.
Abnormal uterine bleeding may be acute or chronic and is defined as bleeding from the uterine
corpus that is abnormal in regularity, volume, frequency, or duration and occurs in the
absence of pregnancy.
Chronic heavy or prolonged uterine bleeding can result in anemia, interfere with daily
activities. Iron deficiency anemia develops in 21 to 67 percent of cases and raises concerns
about uterine cancer.
According to the International Federation of Obstetrics and Gynecology, the classification of
abnormal uterine bleeding is based on PALM-COEIN which is an acronym for various etiologies
namely polyp, adenomyosis, leiomyoma, malignancy and hyperplasia, coagulopathy, ovulatory
dysfunction, endometrial disorders, iatrogenic and not otherwise classified (PALM-COEIN).