Tranexamic Acid and Ethamsylate For Preventing PPH in Patient Undergoing LSCS at High Risk For PPH

• Status: Unknown status
• Trial end date: 2016-07-01
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of this study is to compare the effect of low dose of Tranexamic acid (1gm) and Ethamsylate (1gm) after prophylactic oxytocin administration versus placebo with prophylactic oxytocin given in the 2 minutes after child delivery in patient undergoing LSCS at high risk for post partum hemorrhage

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ahmed Alanwar
• Treatments: Ethamsylate; Tranexamic Acid

Criteria

Inclusion Criteria:

1. Women undergoing elective caesarean section

2. Patient having one or more risk factor for PPH

• Multiple pregnancy

• Polyhydramnios (AFI >25cm)

• Macrocosmic baby (>4.5 Kg)

• Prolonged , augmented and obstructed labour

• Obese patients(BMI >30)

• Premature rapture of membranes

• Previous history of PPH

3. Age ≥18 years

4. Gestational Age ≥ 35 Weeks

5. Informed Oral Consent From The Patient

Exclusion Criteria:

1. History of venous thrombosis (DVT and/or Pulmonary embolism) OR arterial thrombosis (angina pectoris , myocardial infarction, stroke)

2. History of epilepsy or seizure

3. Any Known Cardiovascular , renal or liver Disease

4. Autoimmune Diseases

5. Sickle Cell Disease

6. Severe hemorrhagic Disease

7. Placenta Previa.

8. Morbidly adherent Placenta

9. Abruptio placenta

10. Eclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome

11. Administration Of low molecular weight heparin or Anti platelets the week before delivery .