Transarterial Chemotherapy Compared With Oral Chemotherapy in the Treatment of Advanced Hepatocellular Carcinoma
Status:
Unknown status
Trial end date:
2015-03-01
Target enrollment:
Participant gender:
Summary
In India, majority of our patients have advanced hepatocellular carcinoma (HCC) at
presentation and hence are unsuitable for the available curative treatment options. In such
patients the treatment options are mainly palliative. Transarterial chemoembolization (TACE),
transarterial chemotherapy (TAC) and various forms of oral chemotherapy are the only
available options currently. Many patients have more advanced disease with the involvement of
branches of portal vein. This further limits the therapeutic options. According to Barcelona
Clinic Liver Cancer (BCLC) staging, involvement of portal vein precludes any standard form of
therapy. TAC and oral chemotherapy has been tried in this group of patients by few
researchers. Which treatment (TAC or oral chemotherapy) would be better suitable for advanced
stage (BCLC C) needs to be explored. However, there are no randomized controlled trials
(RCT's) available.
TAC is the procedure for treating patients of HCC with portal vein invasion where only the
chemotherapeutic drugs are injected into the feeding vessels of the tumor with no subsequent
embolization of the feeding vessels.
In order to select a modality which would produce better outcomes in advanced HCC patients
(BCLC C), this study was planned.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
All India Institute of Medical Sciences, New Delhi