Transdermal Delivery of Glucosamine to the Synovial Fluid of Male and Female With Knee Osteoarthritis
Status:
Completed
Trial end date:
2017-03-10
Target enrollment:
Participant gender:
Summary
Glucosamine is commonly used as a treatment for Osteoarthritis (OA). While oral
administration remains the most commonly used route, topical administration could offer
numerous advantages such as targeted delivery to affected joints and overcoming the negative
effects of the passage of the drug through the digestive system. The objective of this study
is to assess the bioavailability of glucosamine in the synovial fluid of osteoarthritic
joints, following the topical application of a commercially available transdermal glucosamine
cream. Joint fluid samples will be collected from 2 groups of participants with knee OA: the
Control group will not be subjected to any treatment while the Test group will apply 2g of
transdermal glucosamine cream 1 to 3 hours before the joint fluid collection. Glucosamine
concentration will be determined and the results obtained from both groups will be compared.
This trial will potentially provide data to support that glucosamine can cross the skin and
be delivered to the affected joint fluid when formulated in a transdermal cream base.
Phase:
Phase 4
Details
Lead Sponsor:
Lynk Biotechnologies Pte Ltd
Collaborators:
T&T Family Health Clinic and Surgery, Singapore Temasek Polytechnic School of Applied Science, Singapore