Transdermal Fentanyl and Melatonin Patches for Postoperative Pain Relief
Status:
Completed
Trial end date:
2015-04-01
Target enrollment:
Participant gender:
Summary
Seventy five patients, aged 18-50 years, ASA I and II undergoing elective single level lumber
laminectomy under general anesthesia were included in this randomized controlled double-blind
study. Patients were randomly divided into 3 groups 25 each, C group patients received
transdermal placebo patch, TDF group (50μg/h) and TDM group (7 mg). Assessment of
postoperative pain, sedation, hemodynamic variables such as HR and MAP, postoperative
monitoring of arterial SpO2 and side effects (e.g. nausea, vomiting, pruritis, respiratory
depression and hemodynamic instability) were done 30 minutes, 1, 2, 6 and 12 hours
postoperatively. Postoperative Patient's and Surgeons' satisfaction, Intraoperative bleeding
and plasma cortisol (µg / dl) postoperatively were also assessed.