Transit Time and Bacterial Overgrowth Using SmartPill Capsule

• Status: Terminated
• Trial end date: 2010-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary purpose of this exploratory study is to measure orocecal transit time using the SmartPill ambulant capsule technology and to compare this with the lactulose hydrogen breath test. Additionally, the ability of the SmartPill GI Monitoring System to discriminate between healthy human subjects and patients with small bowel bacterial overgrowth will be explored using analyses of both pH and pressure patterns within the stomach and small intestine. The study will be performed in both normal subjects and patients with and without small bowel bacterial overgrowth.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mayo Clinic
• Collaborator: The SmartPill Corporation
• Treatments: Lactulose; Rifaximin

Criteria

Inclusion Criteria for Healthy Subjects:

1. Mentally competent and able to give informed consent.

2. Healthy males and females between 18-70 years of age with no current or previous chronic gastrointestinal symptoms.

Inclusion Criteria for Symptomatic Subjects:

1. Males and females between 18-70 years of age with symptoms suggestive of small bowel bacterial overgrowth (e.g., diarrhea, bloating, abdominal discomfort) for at least 3 months during the previous 12 months (need not be consecutive) who recently underwent an evaluation for small bowel bacterial overgrowth by either hydrogen breath testing or culture of small bowel aspirate.

2. Ability to stop laxatives and prokinetic and narcotic analgesic agents 3 days prior to the study and during the study period.

3. Ability to stop proton pump inhibitors 7 days prior to the study and histamine type-2 receptor antagonists (H_2RAs) for 3 days prior to the study and during the study period.

Exclusion Criteria:

1. Subjects who are unable or unwilling to give informed consent or return for all required study visits.

2. Prior gastrointestinal surgery which has altered the anatomy of the esophagus, stomach or small/large intestine (exceptions include appendectomy, cholecystectomy and fundoplication).

3. Hypersensitivity to rifaximin.

4. Use of any medications in the previous week that could alter gastrointestinal motor function.

5. Body Mass Index (BMI) > 38.

6. Previous history of bezoars.

7. Any abdominal surgery within the past 3 months.

8. Known or history of inflammatory bowel disease.

9. History of diverticulitis, diverticular stricture, and other intestinal strictures.

10. Tobacco use within eight hours prior to capsule ingestion and during the initial 8 hour recording on the first day.

11. Alcohol use within eight hours prior to capsule ingestion and throughout the entire monitoring period (up to 5 days).

12. Females of childbearing age who are not practicing birth control and/or are pregnant or lactating (A urine pregnancy test will be performed on female subjects prior to capsule ingestion).

13. Cardiovascular, endocrine, renal or other chronic disease likely to affect motility.

14. Use of medical devices such as pacemakers, infusion pumps, or insulin pumps.