Transplacental Gradients and Transport in Intrauterine Growth Restricted (IUGR) Pregnancies Compared to Normal Pregnancies.

• Status: Suspended
• Trial end date: 2021-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to determine whether the transplacental gradients for 6 polyols and mannose are altered in intrauterine growth restricted (IUGR) pregnancies compared to normal pregnancies and b) to determine the relative contributions of transplacental transport vs production by the conceptus of both inositol (the major polyol) and mannose in IUGR and normal pregnancies using stable isotopic methodology.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Colorado, Denver
• Treatments: Inositol

Criteria

Inclusion Criteria:

• Normal pregnancy = normal fetal growth by ultrasound, absence of congenital anomalies and no maternal complications.

• IUGR = fetal abdominal circumference < 2 Standard Deviations for gestational age

• Scheduled for elective Cesarean section for clinical indications.

• Age 18-50

Exclusion Criteria:

• Presence of maternal infection, chromosomal abnormalities or congenital anomalies

• Multiple pregnancies

• Emergency Cesarean sections

• Diagnosed with Diabetes