Overview

Transplant Antibody-Mediated Rejection: Guiding Effective Treatments

Status:
Active, not recruiting
Trial end date:
2027-07-01
Target enrollment:
Participant gender:
Summary
This trial evaluates the addition of rituximab to standard of care in the treatment of antibody-mediated rejection in kidney transplant patients. The trial will involve adults and children. Half of participants will receive standard of care (methylprednisolone, intravenous immunoglobulin and plasma exchange), while the other half will receive standard of care and rituximab.
Phase:
Phase 3
Details
Lead Sponsor:
Imperial College London
Collaborators:
Cambridge Clinical Trials Unit
Cambridge University Hospitals NHS Foundation Trust
Kidney Cancer UK
National Institute for Health Research, United Kingdom
Treatments:
Antibodies
gamma-Globulins
Immunoglobulins
Immunoglobulins, Intravenous
Methylprednisolone
Methylprednisolone Acetate
Methylprednisolone Hemisuccinate
Prednisolone
Prednisolone acetate
Prednisolone hemisuccinate
Prednisolone phosphate
Rho(D) Immune Globulin
Rituximab