Treating Caregiver Depression to Improve Childhood Asthma: Impact and Mediators
Status:
Completed
Trial end date:
2020-10-01
Target enrollment:
Participant gender:
Summary
The investigators propose a one-year, repeated measures, within-subject design to examine the
impact of improved caregiver depression on child asthma outcomes. A cross-lagged panel
modeling (CLPM) for longitudinal data will be fit using a maximum likelihood structural
equation model (SEM) in order to explore longitudinal mediation between asthma outcomes
(asthma control, spirometry, quality of life (QOL)) and depressive symptoms. CLPM will test
whether caregiver improvement preceded child asthma improvement, and SEM will test whether
improved adherence and/or decreased child anxiety/depression mediated the effect. The
investigators considered a randomized control trial, but it would not be ethically acceptable
to withhold medication from caregivers diagnosed with Major Depressive Disorder (MDD) for the
proposed one-year duration of the study. It is unlikely that potential participants in the
study would find this acceptable. Furthermore a controlled design is not necessary since the
investigators are not testing the efficacy of antidepressants for depression, but rather the
impact of improvement on caregiver depression on the child.
Phase:
Phase 4
Details
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborators:
National Heart, Lung, and Blood Institute (NHLBI) University at Buffalo