Treating Drug-Resistant Childhood Schizophrenia

• Status: Completed
• Trial end date: 2006-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will compare clozapine and olanzapine (Zyprexa®) for the treatment of children and adolescents who have failed standard antipsychotic treatment for schizophrenia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Northwell Health
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Clozapine; Olanzapine

Criteria

Inclusion criteria:

• DSM-IV criteria for treatment-refractory schizophrenia or schizoaffective disorder

• Willingness to use an acceptable form of birth control, if applicable

Exclusion Criteria:

• Neurological or medical disorders that would contraindicate treatment with clozapine or olanzapine

• IQ less than 70

• DSM-IV criteria for substance (other than caffeine or nicotine) related disorder

• Failure of an adequate trial of olanzapine or clozapine