Treating Insulin Resistance as a Strategy to Improve Outcome in Refractory Bipolar Disorder
Status:
Completed
Trial end date:
2020-09-01
Target enrollment:
Participant gender:
Summary
In a previous study by Dr. Calkin, the principal investigator of this study, persons with
bipolar disorder and either type II diabetes or insulin resistance were found to experience
more severe symptoms of bipolar illness and a lower response to treatment, compared to
persons with bipolar disorder who did not have type II diabetes or insulin resistance. To
further explore these findings, the investigators have developed this study to see if
treating insulin resistance (using metformin, a drug used to improve the body's use of
insulin) may also help improve the symptoms of bipolar illness.