Treatmant of Oral Lichen Planus With Lycopene

• Status: Completed
• Trial end date: 2006-07-01
• Target enrollment: 0
• Participant gender: All

Summary

the purpose of this study was to evaluate that if lycopene, a potent antioxidant can be used in the treatment of oral lichen planus. this could be useful as lycopene has no reported side effects and hence it can used in place of steroids which are commonly used for this condition and have many reported adverse effects.

lycopene can be used in the treatment of this condition as free radicals have been found to play a role in the cause of this disease and also lower levels of lycopene were seen in these patints.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: College of Dental Sciences, India
• Treatments: Carotenoids; Lycopene

Criteria

Inclusion Criteria:

1. Patients who were physically healthy and well oriented in time space and as a person.

2. Patients clinically & histopathologically diagnosed to be suffering from oral lichen planus.

3. Patients who had symptoms i.e. pain and/or burning sensation secondary to oral lichen planus.

4. Patients not on any treatment for the same. In case they were, then such treatment was stopped and a washout period of two weeks was given.

5. Patients who agreed to take medication supplied.

6. Patients who were willing for evaluation once in every two weeks for 8 weeks and also agreed to follow up every 30 days for 60 days.

7. Patients who agreed for the biopsy and hematological examination.

Exclusion Criteria:

1. Patients suffering from any systemic disease/s like Diabetes, Hypertension, Cardiovascular system disease, Renal dysfunction, Liver disorders etc.

2. Patients with any other mucosal disease or any other skin disease which may be associated with oral lesions.

3. Patients on any drug therapy which may cause lichen planus like lesions.

4. Patients with findings of any physical or mental abnormality, which would interfere with or be affected by the study procedure.

5. Patients with a known allergy or contraindication to study medications.