Treatment Algorithm for Nausea and Vomiting in the Palliative Phase

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Nausea and vomiting are frequently occurring problems in the palliative phase of patients with cancer. Between 20-50% of them regularly suffer from nausea, retching or vomiting. Often the cause of nausea and vomiting is multifactorial and symptomatic treatment is necessary.

Potential drugs for symptomatic anti-nausea therapy are metoclopramide, serotonin antagonists, the combination of both and dexamethasone as rescue medication in case of failure. There is no data that depicts which strategy is the best. This study will be conducted to unravel which treatment algorithm is most successful.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Radboud University
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Granisetron; Metoclopramide

Criteria

Inclusion Criteria:

• patients 18 years or older in the palliative phase and

• who suffer from nausea or vomiting with a rating on a numeric rating scale (NRS) of more than 2 and

• have a wish to be treated and

• where no treatable cause is assignable

Exclusion Criteria:

• Patients not able to sign informed consent.

• Patients with known contra-indications for metoclopramide, 5HT-3 antagonists or dexamethasone.