Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste

• Status: Completed
• Trial end date: 2015-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the treatment outcomes in permanent teeth with necrotic pulp and immature root development that undergo a regenerative procedure using a triple antibiotic paste (ciprofloxacin, metronidazole, minocycline) versus a double antibiotic paste (ciprofloxacin, metronidazole)compared to the commonly used mineral trioxide aggregate (MTA) apexification treatment.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The University of Texas Health Science Center at San Antonio
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Bacitracin; Bacitracin zinc, neomycin sulfate, polymyxin B, drug combination; Ciprofloxacin; Metronidazole; Neomycin; Polymyxin B

Criteria

Inclusion Criteria:

• diagnosis of pulpal necrosis with apical periodontitis

• patients 7-60 years of age

• maxillary or mandibular restorable single rooted immature permanent tooth with open apices

• acceptance of treatment plan with revascularization procedure

• healthy patient (ASA Class I or II physical status) with no systemic health problems

Exclusion Criteria:

• non-restorable teeth

• patients with ASA Class III or IV physical status (Immuno-compromised patients including patients who self-report to be a carrier of HIV, undergoing steroid therapy, or those who self-report with genetic or systemic diseases that could result in reduced immune response.

• child subjects unable to give assent