Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRI
Status:
Enrolling by invitation
Trial end date:
2025-02-01
Target enrollment:
Participant gender:
Summary
Cerebrovascular disease is a major source of neural injury and there is an urgent need for
comprehensive evaluation of these patients. High-resolution MRI (HR-MRI) allows direct
visualization of intracranial vessel wall pathology in the setting of acute ischemic stroke
and intracranial aneurysm (intracranial aneurysm rupture.Vessel wall enhancement on HR-MRI
results from inflammation and has considerable potential as a marker of future stroke risk or
aneurysm rupture. We will use our HR-MRIvwMRI protocol and other techniques of measuring
plaque and aneurysms vulnerability, including laboratory markers of abnormal inflammation and
oxidization, which have been shown to correlate with vulnerable carotid atherosclerosis and
intracranial aneurysms, but have not been studied in symptomatic ICAS or IA.The unmet need is
a study validating HR-MRI reliability and the association of vessel-wall enhancement with
both symptomatic and pro-inflammatory status in patients with cerebrovascular disease.