Treatment With Alendronate in Patients With Ankylosing Spondylitis (AS)
Status:
Completed
Trial end date:
2016-07-01
Target enrollment:
Participant gender:
Summary
This prospective study will assess the effects of treatment with alendronate in osteoporotic
patients with ankylosing spondylitis.
Primary objectives:
- To investigate if alendronate effect bone mineral density (BMD) assessed by dual energy
x-ray absorptiometry (DXA) in lumbar spine, hip and distal forearm and assessed by
quantitative computed tomography (QCT) in lumbar spine and by Xtreme CT in radius and
tibia.
Secondary objectives:
- To investigate if alendronate effects markers of bone remodeling
- To investigate if alendronate influences disease activity (BASDAI), spinal function
(BASFI), spinal movement (BASMI) and health related quality of life (SF-36).