Treatment With SGLT-2 Inhibitor for Postoperative Hyperglycemia in Acute Abdominal Surgery - a Randomized Trial

• Status: Not yet recruiting
• Trial end date: 2023-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to investigate the effect of an SGLT-2 inhibitor on postoperative hyperglycemia after acute abdominal surgery in patients without diabetes

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zealand University Hospital
• Treatments: Sodium-Glucose Transporter 2 Inhibitors

Criteria

Inclusion Criteria:

• - Admitted to the ward after acute abdominal surgery (ASAP patient at Slagelse Hospital, OMEGA patient at Zealand University Hospital)

• At least two independent measurements of blood glucose above 7.7mmol/l within the first 48 hours after surgery

• Age of 18 to 85

• Must be able to understand and sign informed content

Exclusion Criteria:

• Patients diagnosed with diabetes mellitus

• Impaired kidney function (eGFR < 45mL/min)

• Severe liver disease (defined as transaminases above X 3 normal levels)

• Acute pancreatitis within the last two months or a history of chronic pancreatitis

• Participation in another pharmacological intervention trial

• Predictable poor compliance (for instance mentally impaired)

• Pregnancy or lactation (fertile women must have a negative serum or urine pregnancy test to participate)

• Allergy to study medication